Abstract:Abstract: Objective?To observe the effect of ultrasound-guided single ESP block and TPVB combined with patient-controlled intravenous analgesia (PCIA) on postoperative analgesia in patients undergoing lobectomy performed via videoassisted thoracoscope.?Methods?Forty patients (ASA physical statusⅠorⅡ), scheduled for elective videoassisted thoracoscopic lobectomy, were randomly assigned into two groups, ESP block combined with PCIA group (group P) and TPVB block combined with PCIA group (group C). ESP block was given to patients in group P before operation, TPVB block was given to patients in group C before operation ,and its effect was evaluated by testing the area of block. VAS scores were recorded at l, 6, 12, and 24?h after operation. The frequency for compress PCIA, the volume of analgesic drugs, and the side effects were recorded as well.?Results?ESP block was accomplished in group P with sensory loss from T2?~?T6 or T2?~?T7 over the entire posterolateral aspect of the hemithorax. TPVB block was accomplished in group C with sensory loss from T2?~?T7 over the entire posterolateral aspect of the hemithorax. The VAS scores both at rest and coughing in group P and group C were no significantly different in 1?h, 6?h, 12?h (P?>?0.05), there are different in 18?h and 24?h (P?0.05). The compress PCIA numbers, the volume of analgesic drugs and the consumption of morphine were no significant different (P?>?0.05). Nausea and vomiting were observed as postoperative side effects, and there were no significant differences between the two groups.?Conclusion?Ultrasound-guided single ESP block combined with PCIA is a safer and effective method for the analgesia of thoracic operation.