Abstract:To investigate the clinical efficacy and safety of micro-percutaneous nephrolithotomy for the treatment of special type of kidney stones.?Methods?From June 2016 to August 2017, 46 patients with special type of nephrolithiasis were treated with holmium laser lithotripsy by F4.8 platinoscopy. Among them, 8 cases were calyceal diverticula calculi, the lower calyceal stones (IPA?30°) were in 7 cases, the ureteroscope failed in treatment in 4 cases. And the no collection system expansion kind of renal calculi were in 17 cases, children with renal calculi in 4 cases and postoperative complications of Mainz-II in 6 cases with renal calculi. 28 cases had stone size <1.5?cm, 18 cases had size?>?1.5?cm, the average diameter of stones is (1.6?±?0.4) cm. Located in the lower calyx, middle and upper calyx, renal pelvis combined with calyceal stones were 20 cases, 10 cases, 5 cases and 11 cases. All surgeries were conducted “one puncture to the stone” establishing a path for percutaneous nephrostomy and then lithotripsy.?Results?All the patients were treated with single channel, 35 cases used F4.8 visual nephrolithotomy holmium laser lithotripsy, 11 cases used larger stag horn calculi surgery and then expanded to F20 conducting holmium laser or ultrasonic lithotripsy, surgery time was 25?~?50?min, with an average of (37.4?±?9.2) min. 35 patients were conducted tubeless PCNL and 11 patients underwent nephrostomy or double J catheterization after surgery. No postoperative bleeding occurred in all patients, and 3 patients developed fever. After conventional anti-infective therapy, the symptoms disappeared quickly. The postoperative hospital stay was (2.4?±?0.8) days and the stone clearance rate was 91.3% (42/46) after one month. 4 cases of residual stone patients assisted with extracorporeal shock wave lithotripsy, physical vibration and drugs to promote passing stones, and then follow-up stones were passed net after one month.?Conclusion?F4.8 micro-percutaneous nephrolithotomy is safer and more effective in treating special types of kidney stones. The success rate of surgery is high, the stone clearance rate is high, the complications are few, so the operation is like no bleeding surgery and the patient recovers very fast. It is worthy of clinical application.