Abstract:To explore the minimally invasive surgical treatment for gallbladder patients with common bile duct stones.?Methods?Twenty-two cases of cholecystolithiasis complicated with common bile duct stones treated from January 2013 to January 2018 were selected. The patients were divided into control group (n?=?46) and observation group (n?=?46). Patients with pancreatitis in both groups had first control of peritonitis. Patients in the control group (LC?+?LCBDE) underwent laparoscopic cholecystectomy combined with common bile duct exploration. Patients in the observation group (EST?+?LC) underwent duodenal sphincterotomy. Stone removal was performed and laparoscopic cholecystectomy was performed 3 days after surgery. The perioperative conditions, cost, and complications were compared between the two groups.?Results?No conversion to laparotomy was observed in both groups. The observation time, the use of analgesics, and length of hospital stay in the observation group were all lower than those in the control group. Consumable costs and hospitalization expenses were higher than those in the control group. The difference was statistically significant (P?0.05); There was no significant difference in intraoperative blood loss, postoperative venting time, and surgical cost between the two groups (P?>?0.05). The total incidence of complications in the observation group was 6.51% lower than that in the control group, 19.53%, with a statistically significant difference (P?0.05).?Conclusion?Compared with LC+LCBDE, the treatment of peritonitis with gallbladder complicated with common bile duct stones can reduce the operation time, relieve postoperative pain, reduce the incidence of complications and shorten the hospital stay, but the cost is higher.