Abstract:To investigate the effect of laparoscopic total gastrectomy in patients with gastric cancer.?Methods?132 patients underwent laparoscopic radical gastrectomy for gastric cancer from January 2015 to January 2018 were enrolled. Patients were randomly divided into control group (n?=?66) and observation group (n?=?66). Patients in the observation group were given total laparoscopic radical gastrectomy, while patients in control group were given laparoscopic-assisted radical total gastrectomy. The intraoperative situation, postoperative complications and complications of the two groups were compared.?Results?The length of incision in the observation group was shorter than that in the control group. The distal incision, esophageal jejunum anastomosis time and total operation time were longer than those in control group. The postoperative analgesia time was shorter than that in control group, with significant difference (P?0.05). For the first time, the first time of anus evacuated, the first time eating liquid food, the first time eating semi-liquid food, the time when drainage tube drainage pull out and hospitalization stay had no statistical significance (P?>?0.05). The total complication rates in observation group and control group were 21.19% and 28.76%, respectively, with statistical significance (P?0.05).?Conclusions?Total laparoscopic radical total gastrectomy is more effective than laparoscopic-assisted radical total gastrectomy in the treatment of gastric cancer patients with short duration of postoperative pain and low complication rate, but the esophageal jejunostomy is slightly longer, resulting in longer total operation time.