To observe the effect of endoscopic surgery combined with intracranial pressure monitoring in treatment of hypertensive cerebral hemorrhage, and to explore the effective treatment method.?Methods?From October 2015 to May 2017 we collected 68 cases of hypertensive cerebral hemorrhage patients for the study. The patients were divided into three groups according to the treatment they received, 20 cases endoscopic surgery combined with intracranial pressure monitoring; 25 cases of the transcranial puncture drainage and intracranial pressure monitoring; 23 cases of conventional craniotomy. Then compare the mannitol application times, monitoring time in the intensive care unit, tracheotomy rate, and prognosis of the three groups.?Results?The use of mannitol in endoscopic group (17.25?±?2.55) were less than that in transcranial puncture group (20.32?±?2.08) (P?0.05). The monitoring time in the intensive care unit of endoscopic group (63.60?±?11.74)?h were less than that in the transcranial puncture group (104.64?±?16.80) h and conventional craniotomy group (138.78?±?23.95)?h (P?0.05). The tracheotomy rate of the endoscopic group (5.0%) was less than that in the transcranial puncture group (36.0%) and conventional craniotomy group (34.8%) (P?0.05). The prognosis of the endoscopic group (100.0%) were better than that in the transcranial puncture group (72.0%) and conventional craniotomy group (82.6%) (P?0.05).?Conclusion?Endoscopic surgery combined with intracranial pressure monitoring in treatment of hypertensive cerebral hemorrhage is effective, and can guide clinical scientific and rational development of treatment programs, improve the patients’ prognosis.