Abstract:To analyze the clinical significance of thoracoscopy in treatment of tuberculous pleurisy. ?Methods?We collected 40 cases of tuberculous pleurisy as research objects, 20 patients as treatment groups were diagnosed with tuberculous pleurisy by medical thoracoscopy, while the other 20 patients as control groups, diagnosed by hydrothorax test and tuberculin test by conventional thoracic puncture. Patients in both groups were treated with the same antituberculosis treatment. The hospitalization days and the thoracic puncture times of the two groups was calculated. Then measure the thickness of the pleural fertilizer by chest CT after 12 months of treatment.?Results?There was a statistical difference of the average hospitalization days between the treatment group (9.55?±?1.63)?d and the control group (13.60?±?3.59)?d, P?0.05. The average times of thoracic puncture between the treatment group (1.50?±?0.76)?times, and the control group (2.80?±?0.99)?times, P?0.05, were statistically different, P?0.05. There was a statistical difference of the average pleural fertilizer thickness between the two groups after 12 months’ antituberculosis treatment, the treatment group was (0.15?±?0.09) mm, and the control group was (2.30?±?0.13)?mm, P?0.05.?Conclusion?The use of the medical thoracoscopy to diagnose the patients with tuberculous pleurisy can reduce the days of hospital stay, reduce the frequency of thoracic puncture, and reduce the thickness of the pleural fertilizer. Clinically, if patients is suspected tuberculous pleuritis, it is suggested to give priority to the diagnosis and treatment of medical thoracoscopy.