Abstract:To establish the way and curative effect of joint operation of CO2 laser and low temperature plasma radiofrequency ablation for giant hemangioma of the larynx. Methods We tried to using joint operation of CO2 laser and low temperature plasma radiofrequency ablation for 15 patients with giant hemangioma of the larynx. Results We followed up all the patients from 9 months to three years. One case recurred and treated by minimally invasive operation one more time, without recurrence after two years. The patients with mild pain and their laryngeal function were better protected. All the cases without incision of tracheal and no severe complications such as dyspnea and hemorrhage occurred. Conclusion The joint operation treatment of CO2 laser and low temperature plasma radiofrequency ablation for giant hemangioma of the larynx holds advantages of micro-traumatic, safe and effective, and worthy to be extended on clinical.