复方聚乙二醇电解质散联合硫酸镁给药方法对便秘患者肠道准备的研究

Intestinal preparation of compound polyethylene glycol electrolyte powder combined with Magnesium Sulfate in#br# constipation patients

摘要:

探讨复方聚乙二醇电解质散（SF-PEG）联合硫酸镁（MgSO4）给药方法对便秘患者肠道准备效果的影响。方法 选取拟行结肠镜检查的便秘患者135例，分为A、B、C组，各45例，A组和B组5∶00～7∶00口服SF-PEG 219.2 g（2 000 ml），A组9∶00服50% MgSO4 50 ml，再口服250 ml温水，B组7∶00服相同剂量MgSO4，两组均11∶00行肠镜检查，C组于10∶00～12∶00口服复方SF-PEG 219.2 g（2 000 ml），14∶00服50% MgSO4 50 ml，16∶00行肠镜检查。根据Boston肠道准备量表（BBPS）评分，并行肠腔内气泡评分，统计肠道准备过程持续时间，并记录肠道准备过程中患者的耐受性及不良反应。结果 所有患者完成肠道准备，并顺利行肠镜检查，A组肠镜检查时间明显短于B组和C组（P <0.05）。A组BBPS评分明显高于B组和C组（P <0.05），A组和B组肠腔内气泡评分低于C组，差异有统计学意义（P <0.05）。A、B两组肠道准备时间比C组少，差异有统计学意义（P <0.05），患者耐受性方面，A组和B组高于C组（P <0.05），在不良反应方面，A组和B组低于C组（P <0.05）。结论 择时（5∶00～7∶00）间断服用SF-PEG和MgSO4能缩短便秘患者肠道准备时间、提高肠道准备质量。

Abstract:

Abstract: Objective To investigate the effect of compound polyethylene glycol electrolyte powder (SF-PEG) and Magnesium Sulfate (MgSO4) on intestinal tract preparation in patients with constipation. Methods 135 cases of constipation patients who underwent colonoscopy were selected. They were divided into A, B and C groups, each with 45 cases.Group A and group B received oral SF-PEG and 219.2 g (2 000 ml) at 5:00 to 7:00. Group A take 50% MgSO4 50 ml at 9:00, and then took 250 ml warm water.Group B received the same dose of MgSO4 at 7:00. The two groups were examined by colonoscopy at 11:00. Group C received oral compound SF-PEG 219.2 g (2 000 ml) at 10:00 to 12:00, and then took 50% MgSO4 50 ml at 14:00, received colonoscopy at 16:00. According to the Boston bowel preparation scale (BBPS) score and parallel intraluminal bubble score. Determine the duration of bowel preparation process,and tolerance and adverse effects were recorded during bowel preparation. Results All patients completed bowel preparation and underwent a colonoscopy successfully. The scores of group A in BBPS were significantly higher than those in group B and group C (P < 0.05). In group A and group B, the score of parallel intraluminal bubble was lower than C, which was statistically significant (P < 0.05). The intestinal preparation time of A and B was less than that of group C, which was statistically significant (P < 0.05), and the tolerance of patients was higher in group A and group B than that in group C (P < 0.05). In adverse reactions, group A and group B were lower than those in group C (P < 0.05). Conclusions When taking the time (5:00 to 7:00), intermittent polyethylene glycol electrolyte powder and Magnesium Sulfate can shorten the bowel preparation time and improve the quality of bowel preparation in patients with constipation.