复方聚乙二醇电解质溶液剂量和服用方法对结肠镜前肠道准备的效果评估*

Efficacy evaluation of compound polyethylene glycol electrolyte solution dosage and administration method on bowel preparation before colonoscopy*

摘要:

比较肠道清洁剂复方聚乙二醇电解质溶液（PEG）剂量、服用方法对于结肠镜前肠道准备的效果影响，并比较患者耐受性、不良反应、复检意愿的差别。方法 采用随机、单盲、前瞻性研究的方法，将2017年3月-2017年4月接受结肠镜检查的200例患者，对接受检查患者按预约检查时间随机分为3组，检查前口服PEG剂量及方法分别是2L组60例、（2+1）L组75例、3L组65例。检查时分别对右半结肠、横结肠、左半结肠的肠道准备效果进行波士顿肠道准备评估量表（BBPS）计分，记录3组患者的耐受性、不良反应、复检意愿，并进行统计分析。结果 按标准纳入研究患者共计184例，其中2L组58例，（2+1）L组70例，3L组56例。（2+1）L组、3L组的结肠清洁程度BBPS总体评分均高于2L组评分，差异有统计学意义（P <0.05）。（2+1）L组、3L组患者的BBPS总体评分差异无统计学意义（P >0.05），3L组的右半结肠评分高于（2+1）L组。2L组、（2+1）L组患者耐受性、不良反应、复检意愿均优于3L组患者。结论 结肠镜检查前服用（2+1）L PEG溶液较2L方案能获得更好的肠道准备质量，同时又较3L方法降低了患者的不良反应，提高了耐受性、复检意愿，值得推广。

Abstract:

Abstract: Objective To assess the efficacy of bowel preparation and tolerability, adverse reactions, re-examination willingness in different dose and taking method of compound polyethylene glycol electrolyte solution (PEG) before colonoscopy. Method This was a prospective, randomized, single-blind trial. From March 2017 to April 2017, 200 patients underwent colonoscopy were randomized to 3 group as 2L group (n = 60), (2+1)L group (n = 75) or 3L group (n = 65). The primary outcome was preparation quality from procedure photos using the Boston Bowel Preparation Scale. Additional aims of this study were to compare patient’s tolerability, side reaction, and the re-examination willingness. Results Over the course of the study we identified 184 eligible outpatients to participate in the study, including 2L group (n = 58), (2+1)L group (n = 70) and 3L group (n = 56). The average of BBPS scores for (2+1)L group and 3L group were higher than 2L group’s score (P < 0.05). The scores according to BBPS of the (2+1)L
group and 3L group were similar (P > 0.05) but the score of right colon of 3L group was higher than (2+1)L group (P < 0.05). The tolerability, adverse reactions and re-examination willingness of 2L group and (2+1)L group were better than 3L group (P < 0.05). Conclusions The (2+1)L PEG preparation for colonoscopy had higher efficacy than 2L PEG, reduced the adverse reaction of patients and improved the tolerance and the re-examination willingness.