不同肠道准备方法对胶囊内镜检查的效果研究*

Comparison of different bowel preparation methods for capsule endoscopy*

摘要:

摘要：目的  探寻胶囊内镜（CE）检查的最佳肠道准备方法。方法 102例拟行CE检查的患者随机分为3组，A组（n =40）：检查前1天21：00口服聚乙二醇电解质散137.12 g，溶于2 000 ml水中，检查前4 h口服聚乙二醇电解质散68.56 g，溶于1 000 ml水中；B组（n =32）：检查前4 h口服聚乙二醇电解质散205.68 g，溶于3 000 ml水中；C组（n =30）：检查前4 h口服20%甘露醇500 ml，后饮水2 500 ml。3组患者均吞服胶囊后立即吞服二甲基硅油120 mg，比较各组患者副反应发生率、小肠清洁度和小肠通过时间。结果 3组副反应发生率分别为15.00%、15.63%及16.67%，差异无统计学意义（P >0.05）；B、C两组小肠清洁度均优于A组，差异具有统计学意义（均P <0.05），C组略优于B组，差异无统计学意义（P >0.05）；A组小肠通过时间明显长于B、C两组（均P <0.05），而B、C两组间比较差异无统计学意义（P >0.05）。结论 清肠剂顿服效果优于分次口服，20.00%甘露醇500 ml顿服是一种清肠效果好、副反应较少且经济的肠道准备方法，值得临床推广。

Abstract:

Abstract: Objective To explore the optimal bowel preparation for capsule endoscopy (CE). Methods 102 patients were recruited for CE and randomly divided into 3 groups. The group A (n = 40) : patients received polyethylene glycol electrolyte powder (PEG) 137.12 g dissolved in 2 000 ml water at 21:00 one day prior to CE, and taken PEG 68.56 g dissolved in 1 000 ml of water four hours before the procedure. Group B (n = 32): patients received PEG 205.68 g dissolved in 3 000 ml of water four hours prior to CE. Group C (n = 30): patients used a 500 ml 20% mannitol and 2 500 ml water bowel preparation four hours prior to CE. All patients were treated with 120 mg simethicone immediately after swallowing CE. The incidences of adverse events, small-bowel preparation quality and transit time were analyzed. Results The adverse effects rate in each group was similar (15.00%, 15.63% vs 16.67%, P > 0.05). The small-bowel preparation quality was better in both B and C groups than A group (P < 0.05). In the C Group, small-bowel preparation quality was slightly better than the B group, but the difference was not statistically significant (P > 0.05). In comparison with patients in both B and C groups, those in A group had a longer small-bowel transit time (P < 0.05), whereas there was no significant difference between B and C group (P > 0.05). Conclusion Bowel cleansing effect was better in single dose regimen than split dose protocol. The single dose regimen of 500 ml 20% Mannitol for bowel preparation is suitable prior to CE.