腹腔镜下子宫肌瘤剔除术治疗子宫肌瘤以及对患者IL-6、IL-2 和CRP 的影响

Imapct of laparoscopic myomectomy on IL-6, IL-2, and CRP in patients with uterine fibroids

摘要:

目的 探讨腹腔镜下子宫肌瘤剔除术治疗子宫肌瘤的效果。方法 选取2015 年2 月－ 2016 年2 月在该院治疗的子宫肌瘤患者84 例。其中，接受腹腔镜下子宫肌瘤剔除术患者51 例（观察组），接受经腹子 宫肌瘤剔除术患者33 例（对照组），观察两组手术时间、术中出血量等情况，同时检测患者手术前后C 反应 蛋白（CRP）、白细胞介素-2（IL-2）、白细胞介素-6（IL-6）、促卵泡生成素（FSH）、黄体生成素（LH） 及窦状卵泡（AFC）的情况。结果 观察组手术时间为（74.29±13.20）min，明显多于对照组（P <0.05）； 观察组术中出血量、术后排气时间、住院天数及术中肌瘤剔除数分别为（105.39±32.04）ml、（17.40±2.31）h、 （4.02±1.32）d 和（6.02±1.32）个，明显少于对照组（P <0.05）；观察组术后CRP 和IL-6 分别为（25.20± 5.32）mg/L 和（38.04±10.11）ng/ml，明显低于对照组（P <0.05），而IL-2 为（46.13±13.10）ng/ml，明显 高于对照组（P <0.05）；两组手术前后FSH、LH 及AFC 比较差异无统计学意义（P >0.05）；观察组术后并 发症发生率为3.92%，明显低于对照组（P <0.05）；观察组术后复发率和妊娠率分别为21.56% 和54.90%，与 对照组比较差异无统计学意义（P >0.05）。结论 腹腔镜下子宫肌瘤剔除术治疗子宫肌瘤是安全有效的，患 者应激反应小，对卵巢功能无影响。

Abstract:

Objective To investigate the effect of laparoscopic myomectomy for uterine fibroids. Methods From February 2015 to February 2016, 84 cases of uterine fibroids were selected, 51 patients underwent laparoscopic myomectomy (observation group), and 33 patients received abdominal myomectomy (control group), the operation time and intraoperative blood loss and so on were observed in two groups, C reactive protein (CRP), interleukin-2 (IL-2), IL-6, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and antral follicle (AFC) were detected before and after operation. Results The operation time of the observation group was (74.29 ± 13.20) min, significantly higher than the control group (P < 0.05), the amount of bleeding, postoperative exhaust time, hospitalization time and intraoperative myoma rejection number were (105.39 ± 32.04) ml, (17.40 ± 2.31) h, (4.02 ± 1.32) d and (6.02 ± 1.32), significantly less than the control group (P < 0.05); The CRP and IL-6 in the observation group were (25.20 ± 5.32) mg/L and (38.04 ± 10.11) ng/ml, significantly lower than those in the control group (P < 0.05), while IL-2 was (46.13 ± 13.10) ng/ml, was significantly higher than that of the control group (P < 0.05); The incidence of postoperative complications in the observation group was 3.92%, which was significantly lower than that in the control group (P < 0.05); There was no significant difference in the levels of(FSH, LH and AFC between the two groups (P > 0.05); The postoperative recurrence rate and pregnancy rate in the observation group were 21.56% and 54.90%, compared with the control group, there was no significant difference (P > 0.05). Conclusion Laparoscopic myomectomy is safe and effective in treatment of uterine fibroids with less stress response and no effect on ovarian function.