右美托咪定对胸腔镜下肺癌根治术患者炎症因子的影响

Effect of Dexmedetomidine on inflammatory mediators in thoracoscopic radical resection of lung cancer

摘要:

目的 探讨右美托咪定对胸腔镜下肺癌根治术患者炎症因子的影响。方法 选择美国麻醉医师 协会（ASA）分级为Ⅰ或Ⅱ级的胸腔镜下肺癌根治术患者120 例，随机分为右美托咪定组（Ⅰ组）与对照组（Ⅱ 组），每组60 例。并分别在麻醉诱导前（T0）、术毕即刻（T1）、术后12 h（T2）、24 h（T3）抽取外周血测定白 细胞介素-8（IL-8）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）的水平。结果 两组患者术后 T1 和T2 外周血IL-8、IL-6 和TNF-α 比T0 升高，Ⅰ组术后IL-8、IL-6 和TNF-α 明显低于Ⅱ组（P <0.05）。 结论 右美托咪定能减少胸腔镜下肺癌根治术患者围术期血清炎症因子IL-8 和IL-6、TNF-α 的水平，对 抑制手术引起的过度炎症反应有一定意义。

Abstract:

Objective To investigate the effects of Dexmedetomidine on inflammatory mediators in thoracoscopic radical resection of lung cancer. Methods 120 thoracoscopic radical resection of lung cancer patients ASA Ⅰ or Ⅱ underwent selective operation were randomly divided into two groups: Dexmedetomidine anesthesia (group Ⅰ ) and control group (group Ⅱ ), 60 cases in each. In either group, peripheral venous blood was collected at the following time points: before anesthesia induction (T0), the end of the operation (T1), 12 h (T2) and 24 h (T3) after operation, and the serum concentration of IL-8, IL-6 and TNF-α were measured. Results The concentration of IL-8, IL-6 and TNF-α at T1, T2 were higher than that at T0, and the levels of IL-8, IL-6 and TNF-α in group Ⅰ lower than that in group Ⅱ (P < 0.05). Conclusion Dexmedetomidine can decrease the level of TNF-α, IL-6 and IL-8 in serum of patients thoracoscopic radical resection of lung cancer. This may inhibit excessive inflammation response of patients.