不同程度精索静脉曲张不育患者精索静脉高位结扎术后精子DNA 碎片分析

Analysis of the sperm DNA fragmentation in different degrees of varicocele infertility patients after high ligation of the spermatic vein

摘要:

目的 分析不同程度精索静脉曲张（VC）不育患者行精索静脉高位结扎术后精子DNA 碎片的 情况。方法 不同程度VC 不育患者57 例。其中，诊断为2 级患者27 例，3 级患者30 例。所有患者行精索 静脉高位结扎术前1 个月及术后3 个月检测并计算精子DNA 碎片指数（DFI）。结果 57 例VC 不育患者均 行腹腔镜双侧精索静脉高位结扎术。VC 2 级和3 级患者行手术治疗后精子DFI 与术前比较均值降低，差异有 统计学意义（P <0.05）。治疗前VC 2 级和3 级不育患者精子DFI 比较差异无统计学意义（P >0.05）；治疗后 2 级患者精子DFI 低于3 级患者（P <0.05），DFI 改善情况优于3 级患者（P <0.05）。结论 腹腔镜精索静脉 高位结扎术能够改善VC 不育患者精子DNA 碎片情况，对于2 级患者效果更佳。

Abstract:

Objective To analyze the sperm DNA fragmentation in different degrees of varicocele (VC) infertility patients after high ligation of the spermatic vein. Methods There were 57 patients with different degrees of VC infertility patients. 27 patients had been diagnosed with level two VC, and 30 patients had been diagnosed with level three VC. All patients’ sperm DNA fragmentation index (DFI) were detected and calculated at preoperative one month and postoperative three months. Results 57 VC infertility patients were all suffered from laparoscopic high ligation of the spermatic vein on both sides. There was no statistically difference on preoperative sperm DFI between level two and level three patients (P > 0.05). All patients’ sperm DFI were decreased after laparoscopic (P < 0.05), and level two VC infertility patients had significant greater progress than level three patients (P < 0.05). Conclusion Laparoscopic high ligation of the spermatic vein can effectively improve VC infertility patients sperm DFI. It would be better for level two VC infertility patients.