羟考酮与舒芬太尼用于腹腔镜胆囊切除术麻醉诱导的效果比较

Comparison of Oxycodone and Sufentanil applied in laparoscopic cholecystectomy anesthesia induction

摘要:

目的 比较盐酸羟考酮与枸橼酸舒芬太尼用于腹腔镜胆囊切除术（LC）麻醉诱导的麻醉及镇 痛效果。方法 择期LC 术患者60 例，美国麻醉医师协会分级（ASA）Ⅰ或Ⅱ级，采用随机数字表法分为两 组：羟考酮组（O 组）及舒芬太尼组（S 组）。麻醉诱导：O 组：静脉注射丙泊酚1.0 ～ 2.0 mg/kg、羟考酮 0.3 mg/kg、维库溴铵0.1 mg/kg ；S 组：静脉注射丙泊酚1.0 ～ 2.0 mg/kg、舒芬太尼0.3 μg/kg、维库溴铵 0.1 mg/kg。麻醉维持采用常用的静吸复合药物。记录入手术室后（T0）、麻醉诱导后置入喉罩前（T1）、麻醉 诱导置入喉罩后1 min（T2）、建立人工气腹后（T3）、分离胆囊时（T4）、苏醒即刻（T5）和离开复苏室即刻（T6） 时的心率（HR）、收缩压（SBP）、舒张压（DBP），记录苏醒即刻（T5）、离开复苏室即刻（T6）、术后4 h（T7）、 术后8 h（T8）和术后第1 天（T9）的疼痛数字等级评分（NRS），记录苏醒时间及术毕患者复苏过程中追加 止痛药例数，观察术后患者不良反应情况。结果 两组患者术中平均HR、SBP 及DBP 波动不超过基础值的 20.0%。两组患者术毕苏醒时间无明显差异。S 组苏醒后补救镇痛的比率为36.7%，较O 组更多（P =0.040）。 O 组较S 组在T5、T7、T8 和T9 等时间点疼痛NRS 评分更低，但是差异无统计学意义。两组患者不良反应情 况比较无明显差异。结论 0.3 mg/kg 羟考酮与舒芬太尼0.3 μg/kg 用于LC 手术麻醉诱导，患者麻醉及镇痛 效果良好，能满足临床麻醉及术后镇痛需求。0.3 mg/kg 的羟考酮有与0.3 μg/kg 的舒芬太尼相当或更好的镇 痛作用。

Abstract:

Objective To compare the analgesia effects of Oxycodone hydrochloride with Sufentanil in laparoscopic cholecystectomy (LC) anesthesia induction. Method Sixty patients scheduled for elective LC, ASA Ⅰ or Ⅱ , were randomly divided into two groups (30 in each): Oxycodone group (group O) and Sufentanil group (Group S). Induction of anesthesia: group O: Propofol 1.0 ~ 2.0 mg/kg, Oxycodone 0.3 mg/kg, Vecuronium 0.1 mg/kg. Group S: Propofol 1.0 ~ 2.0 mg/kg, Sufentanil 0.3 μg/kg and Vecuronium 0.1 mg/kg. The value of HR, SBP, DBP of the two groups were recorded in the operation room (T0), after anesthesia induction (T1), 1 min after insertion laryngeal mask (T2), the instant of pneumoperitoneum establishment (T3), separation of the gallbladder (T4), the time of wake up (T5), leave the recovery room (T6). The numeric pain rating scale (NRS) were recorded at T4, T5, 4 hours later (T7), 8 hours later (T8), one day later (T9). Then recorded the wake time and additional analgetic cases. Recorded the adverse reactions. Results The average HR, SBP and DBP fluctuations in the two groups were not more than 20.0 % of the basal values. There was no significant difference in wake time between the two groups. There were 11 cases of patients, the NRS>4, in Sufentanil group requires additional analgesics after they wake up, more than Oxycodone group (P = 0.040). The NRS score was lower in Oxycodone group than group S in T5, T7, T8, T9, but they had no statistically significant difference. There was no significant difference in adverse reactions between the two groups. Conclusion 0.3 mg/kg Oxycodone and 0.3 μg/kg Sufentanil for anesthesia induction of LC, the anesthesia and analgesia effect is good, can satisfy the clinical anesthesia and postoperative analgesic requirements. The analgesic effect of 0.3 mg/kg Oxycodone may be comparable or better than 0.3 μg/kg Sufentanil.