改良肠道准备法在便秘患者肠镜检查中的应用

Effect of modified bowel preparation in patients with constipation undergoing colonoscopy

摘要:

目的??评价改良肠道准备法复方聚乙二醇电解质散（SF-PEG，舒泰清）联合硫酸镁在便秘患者结肠镜检查肠道准备的效果。方法?取行结肠镜肠道准备的轻中度便秘患者60例，随机分为两组：A组，常规剂量SF-PEG（438.4 g，4 L），30例；B组，续服贯用SF-PEG（219.2 g，2 L）和硫酸镁（50.00% 50 ml，再口服250 ml温开水），30例。Boston肠道准备量表（BBPS）、肠腔内气泡评分和结肠镜检查时间由同一内镜医师单盲记录，药物耐受性、再次肠道准备接受率和不良反应采用患者问卷调查。结果?所有患者均完成肠道准备和结肠镜检查。B组结肠镜检查时间短于A组（P <0.05）；B组BBPS总分高于A组（P <0.05）；B组肠腔内气泡评分明显低于A组（P <0.05）；B组再次肠道准备接受率明显高于A组（P <0.05）。A、B两组口感和总体不良反应发生情况评分无明显差异（P >0.05）。结论?应用SF-PEG联合硫酸镁法，对轻中度便秘患者行结肠镜检查，具有耐受性好、清洁度高、镜检效果好和安全可靠等优点，推荐临床应用。

Abstract:

Objective?To evaluate the effect of modified bowel preparation-Polyethylene Glycol Electrolytes Powder (SF-PEG, Shu Taiqing) in combination with magnesium sulfate in patients with constipation undergoing colonoscopy.?Methods?Sixty cases from mild to moderate constipation were randomly divided into two groups: Group A: SF-PEG (438.4 g, 4 L), 30 cases; Group B: received low-dose SF-PEG (219.2 g, 2 L) and 50.00% magnesium sulfate 50 ml, and then 250 ml water, 30 cases. Boston Bowel Preparation Scale scores (BBPS) and bubbles in bowel lumen score were assessed by the same endoscopist blindly to the preparation regimen, and the time of colonoscopy and the tolerability was recorded.?Results?All patients underwent completely the bowel preparation and colonoscopy. The time of colonoscopy of group B was shorter than that of group A (P < 0.05). The BBPS score of group B was higher than that of group A (P < 0.05). The bubbles in bowel lumen were less in Group B than in Group A (P < 0.05). The willingness to retake in Group B were superior to those in Group A (P < 0.05). No significant difference was found in score of total adverse effects and taste score between the two groups (P > 0.05).?Conclusion?SF-PEG in combination with magnesium sulfate in patients with constipation for colonoscopy can improve tolerance to bowel preparation, cleanliness and effects of examination. It’s safe to be recommended in clinical practice.