不同服药速度对聚乙二醇电解质溶液肠道准备的效果评价*

Evaluation of different administration speed on Polyethylene glycol electrolyte solution for colonoscopy preparation*

摘要:

目的??评价复方聚乙二醇电解质溶液（PEG-ES）不同服药速度作为肠道准备方案的清洁效果和耐受性。方法?连续纳入97例拟行肠镜检查患者，随机分为A组（试验组）和B组（对照组）。A组：2 000 ml PEG-ES，每10～20 min内快速服用1 000 ml，1 h内服完。B组：2 000 ml PEG-ES，每10 min服用250 ml，2 h内服完。观察指标：总服药时间、服药后第一次排便时间、总排便次数、Boston肠道准备量表（BBPS）评分和不良反应发生情况。结果?A组与B组间性别、年龄和盲肠插管率差异无统计学意义（P > 0.05）。A组服药时间、首次排便时间明显短于B组，而总排便次数明显多于B组（P <0.05）。两组患者均未出现呕吐及腹痛等不良发应，但A组恶心及腹胀发生率高于B组（P <0.05），但发生率均小于10.00%。A组患者肠道准备接受率低于B组，但均超过90.00%，A组再次肠镜检查接受率明显高于B组（P <0.05）。A组右半结肠、横结肠评分及总分明显高于B组（P <0.05），但左半结肠评分差异无统计学意义（P >0.05）。结论?两种方案均能满足常规结肠镜检查的要求，1 h内快速服PEG-ES的结肠镜检查肠道准备方案能获得更满意的肠道清洁效果。

Abstract:

Objective?To evaluate the cleanliness and tolerance of different administration speed on polyethylene glycol electrolyte solution (PEG-ES) for colonoscopy preparation.?Methods?97 consecutive asymptomatic individuals underwent colonoscopy and therapy were enrolled and randomly assigned into 2 groups. Subjects in group A drank 2 000 ml PEG-ES (1 000 ml every 10 ~ 20 min rapidly) within 1 h before colonoscopy; Subjects in group B drank 2 000 ml PEG-ES (250 ml every 10 min) within 2 h before colonoscopy. The total time of drinking PEG-ES, the first defecation time and total numbers of defecation after drinking PEG-ES, score and degree of Boston bowel preparation scale (BBPS) and PEG-ES related adverse effects of the two groups were assessed and compared.?Results?There were no significant differences in gender, age and cecal insertion rate between group A and group B (P > 0.05). The total time of drinking PEG-ES, the first defecation time in group A were significant faster than those in group B, while total numbers of defecation was significantly more than that in group B (P < 0.05). No patients in the two groups complained PEG-ES related bellyache and vomiting, a little subjects in group B complained PEG-ES related nausea and bloating (P < 0.05), but the incidence were both less than 10.00 %. Accepting rate of colonoscopy preparation in group A was lower than that in group B, but both more than 90.00%, while accepting rate of re-colonoscopy than that in group B. BBPS score of the right half colon, transverse colon, total colon were significantly higher in group A than that in group B respectively (P < 0.05), while that of the left colon no significant differences between the two groups (P > 0.05).?Conclusions?Both regimens met the requirement of conventional colonoscopy and therapy, while rapid drinking PEG-ES within 1 h provides more better colonic cleansing quality for colonoscopy preparation.