年龄因素对行内镜黏膜下剥离术治疗早期单一病灶胃癌患者围手术期临床指标和肿瘤切除效果及并发症的影响

Influence of age on perioperative clinical parameters, tumor resection effects and complications of patients with early stage gastric cancer for single lesion treated by ESD

摘要:

目的??探讨年龄因素对行内镜黏膜下剥离术（ESD）治疗早期单一病灶胃癌患者围手术期临床指标、肿瘤切除效果及并发症的影响。方法?研究对象选取该院2013年1月-2014年7月收治早期单一病灶胃癌患者共60例。其中，年龄<65岁共35例设为A组，年龄≥65岁设为B组，均采用ESD术式治疗，比较两组患者手术时间、术中出血量、住院时间、肿瘤治愈性切除率、肿瘤完整切除率、随访复发率及并发症发生率等。结果?两组患者手术时间、术中出血量及住院时间比较差异无统计学意义（P >0.05）；两组患者肿物治愈性切除率和完整切除率比较差异无统计学意义（P >0.05）；两组患者术后12和24个月复发率比较差异无统计学意义（P >0.05）；同时两组患者术后出血和穿孔发生率比较差异无统计学意义（P >0.05），均无术中出血病例。结论?老年早期单一病灶胃癌患者行ESD术式治疗可获得与中青年患者相近临床近远期疗效，且未增加手术时间、术中创伤程度及并发症发生风险。

Abstract:

Objective?To investigate the influence of age on perioperative clinical parameters, tumor resection effects and complications of patients with early stage gastric cancer for single lesion treated by ESD.?Methods?60 patients with early stage gastric cancer for single lesion treated by ESD were chosen from January 2013 to July 2014 and divided into 2 groups including A group (35 patients) with < 60 years old and B group (25 patients) with ≥ 60 years old; and the operation time, intraoperative blood loss, hospital staying time, tumor curative resection and completed rate, the recurrence rate with follow-up and complications incidence of 2 groups were compared.?Results?All the patients were successfully performed the operation and no bleeding cases. There was no significant difference in the operation time, intraoperative blood loss, hospital staying time between 2 groups (P < 0.05). There was no significant difference in the tumor curative resection and completed rate between the 2 groups (P < 0.05). There was no significant difference in the recurrence rate with follow-up between 2 groups (P < 0.05). There was no significant difference in the complications incidence between 2 groups (P < 0.05).?Conclusion?ESD is safe and feasible in the treatment of elderly patients with early stage gastric cancer for single lesion, and it is equivalent to short- and long-term efficacy in non-elderly patients and not increase the operation time, the trauma degree and complications risk.