注射显色剂浓度对行内镜黏膜下剥离术治疗的肠道肿瘤患者的影响

Influence of injection color regents concentration on completed resection rate, operation time and injection volume of patients with intestinal tumor by ESD

摘要:

目的??探讨注射显色剂浓度对行内镜下黏膜剥离术（ESD）治疗肠道肿瘤患者完整切除率、手术时间及注射用量的影响。方法?研究对象选取该院2013年6月-2016年6月行ESD术治疗肠道肿瘤患者共90例，以随机数字表法分为A组（30例）、B组（30例）及C组（30例），分别给予甘油果糖肾上腺素混合液单用，2%及4%亚甲蓝甘油果糖肾上腺素混合液行术中肠道黏膜下注射，比较3组患者肿物完整切除率、手术时间、注射剂用量及围手术期并发症发生率等。结果?3组患者肿物完整切除率比较差异无统计学意义（P >0.05）；C组患者手术时间和注射剂用量均明显优于A组和B组（P <0.05）；A组和B组患者手术时间和注射剂用量比较差异无统计学意义（P >0.05）；3组患者围手术期并发症发生率比较差异无统计学意义（P >0.05）。结论?4%亚甲蓝+甘油果糖肾上腺素混合液用于行ESD术治疗肠道肿瘤患者可有效缩短手术操作用时，减少黏膜下液体注射剂量，价值优于2%亚甲蓝+甘油果糖肾上腺素混合液及甘油果糖肾上腺素混合液单用。

Abstract:

Objective?To investigate the influence of injection color regents concentration on completed resection rate, operation time and injection volume of patients with intestinal tumor by ESD.?Methods?90 elderly patients with intestinal tumor by ESD were chosen from June 2013 to June 2016. They were randomly divided into 3 groups including A group (30 patients) with glycerin fructose used alone, B group (30 patients) with glycerin fructose combined with 2% mythylene blue on the basis of glycerin fructose and C group (30 patients) with glycerin fructose combined with 4% mythylene blue on the basis of glycerin fructose; and the completed resection rate of tumor, operation time, injection volume and complication incidence in the peri-operative period of 3 groups were compared. ?Results?There was no significant difference in the completed resection rate of tumor among the 3 groups (P < 0.05). The operation time and injection volume of C group were significant better than A group and B group (P < 0.05). There was no significant difference in operation time and injection volume between A group and B group (P < 0.05). There was no significant difference in the complication incidence in the peri-operative period among the 3 groups (P < 0.05).?Conclusion?Compared with glycerin fructose used alone and glycerin fructose combined with 1% mythylene blue for 2 mg, glycerin fructose combined with 1% mythylene blue for 4 mg by intestinal submucosal injection on patients with intestinal tumor by ESD can efficiently shorten the operation time and reduce the injection volume.