内镜下黏膜剥离术治疗胃间质瘤的有效性及安全性分析

Endoscopic subcucosal dissection in treatment of gastric stromal tumors

摘要:

目的??探讨内镜下黏膜剥离术（ESD）治疗胃间质瘤的临床价值。方法??回顾性分析2012年6月-2015年12月该院收治的胃间质瘤（直径≤3 cm）患者56例，所有患者均采用ESD方式治疗。分析病例的完整切除率、并发症发生率及术后有无复发等。结果??54例（96.4%）成功完成ESD，2例因出血、穿孔转外科行开腹手术。术后病理以及免疫组织化学结果显示CD117阳性51例（91.1%）、CD34阳性47例（83.9%）。术后随访3～48个月，随访期间无复发病例。结论??ESD是治疗相对小的胃间质瘤安全、有效的手术方式。

关键词:胃间质瘤;内镜下黏膜剥离术;治疗

Abstract:

Objective?To elavuate the clinical value of endoscopic subcucosal dissection (ESD) in treatment of gastric stromal tumor.?Methods?This is a retrospective cohort study. From June 2012 to December 2015, 56 patients with gastric stromal tumor (diameter ≤3 cm) underwent ESD were enrolled. Clinical outcomes including complete resection, postoperative complications and recurrent rate were analyzed.?Results?54 patients (96.4 %) were successfully treated with ESD, while the other 2 patients (3.6 %) suffered severe complications (hemorrhage or perforation). Postoperative pathologic and immunohistochemical results showed that CD117 in 51 cases was positive (91.1 %), CD34 in 47 cases was positive (83.9 %). No recurrence was detected between 3-month and 48-month follow-up period.?Conclusion?This study showed that ESD was a safe and effective treatment for gastric stromal tumors.

Key words:gastric stromal tumors; endoscopic subcucosal dissection; therapy