Abstract:Objective?To evaluate the technical feasibility and clinical efficacy of the single channel minimally invasive percutaneous nephrolithotomy combined with choledochoscope holmium laser lithotripsy. Methods?48 cases of complicated upper urinary calculi by operation from Jun 2013 to Dec 2015.The relevant factors of clinical outcomes were alaysized. Results?48 patients were in stageⅠsuccessfully established percutaneous renal access, one-stage stone clearance rate was 93.18 %, the average operation time (95.0 ± 16.0) min; the average time of stone processing (64.0 ± 10.0) min, no serious complication occurred in all patients. Conclusions?Minimally invasive endoscopic hard choledochoscope holmium laser lithotripsy for treatment of complicated upper urinary calculi has obvious curative effect, less complications, and a high stone clearance rate, reduce the risk of bleeding.