25例不明原因胸腔积液患者内科电子胸腔镜检查结果分析

Clinical analysis of patients with pleural effusion of unknown causes examined by flexi-rigid thoracoscopy (25 cases)

摘要:

目的 探讨内科电子胸腔镜在不明原因胸腔积液诊断中的临床应用价值及与血清癌胚抗原（CEA）、胸苷激酶1（TK1）及胸水腺苷脱氨酶（ADA）的相关性。方法 回顾性分析2015年1月-2015年11月该科接受可弯曲内科电子胸腔镜检查的25例不明原因胸腔积液患者临床病理资料及血清CEA、TK1及胸水ADA检查结果。结果 在25例不明原因的胸腔积液患者中，有22例得以明确诊断，确诊率高达88.00%。包括恶性胸腔积液9例（36.00%），结核性胸腔积液11例（44.00%），炎性胸腔积液2例（8.00%），未能明确诊断胸腔积液3例（12.00%）；恶性组TK1血、CEA胸水/CEA血阳性率明显高于结核组和炎性组，结核组ADA胸水阳性率明显高于恶性组和炎性组。结论 内科电子胸腔镜检查确诊率高，创伤性小，并发症少，安全性高，是诊断不明原因胸腔积液的有效手段，有着广泛的临床应用前景，与血清CEA、TK1及胸水ADA等相结合有助于提高不明原因胸腔积液的确诊率。

Abstract:

Objective To investigate the value of flexi-rigid thoracoscopy in pleural effusion of unknown causes and the correlation with CEA, TK1 and ADA. Methods The clinical data and results of CEA, TK1 and ADA of 25 patients were retrospective analyzed in our department from 2015 January to November 2015. These patients accepted the examination of flexi-rigid thoracoscopy with pleural effusion of unknown causes. Results In the 25 patients with pleural effusion of unknown causes, definite diagnosis was made in 22 cases (88.00 %), of which 9 cases were malignant pleural effusion (36.00 %), 11 cases were tuberculous pleural effusion (44.00 %), 2 cases were inflammatory pleural effusion (8.00 %), 3 cases were undetermined (12.00 %). The positive rate of TK1 and CEA in malignant group was significantly higher than that in the tuberculosis group and inflammatory group, the positive rate of ADA in the tuberculosis group was significantly higher than that in the malignant group and inflammatory group. Conclusion Flexi-rigid medical thoracoscopy examination is an effective and safe method for diagnosis of unexplained pleural effusion with high exact diagnosis rate, less trauma and less complication. Combination with CEA, TK1 and ADA are helpful to improve diagnostic rate of pleural effusion of unknown causes.