腹腔镜微创治疗胃部胃肠间质瘤的近期临床效果研究

Short-term effect of minimally invasive treatment for gastric stromal tumors

摘要:

目的 比较腹腔镜微创治疗和开腹手术治疗胃部胃肠间质瘤（GIST）的近期临床效果。方法 选取肿瘤局限且经手术后病理证实的26例胃部GIST患者的临床资料，根据手术方式分为腹腔镜手术组（n =12）与开腹手术组（n =14）。两组患者在年龄、性别比例、病程时间、临床症状、肿瘤发生部位和病变大小等临床资料的比较差异无统计学意义（P >0.05），具有可比性。分析比较两组患者的手术结果、术中出血量、手术时间、术后住院时间、术后排气时间、术后进流质时间以及相关并发症发生率。结果 两组患者手术均获得R0根治性切除；腹腔镜手术组的术中出血量、手术时间、术后住院时间、术后排气时间和术后进流质时间均低于开腹手术组（P <0.05）；腹腔镜手术组的相关并发症发生率与开腹手术组比较，差异无统计学意义（P >0.05）。结论 腹腔镜手术切除胃部GIST能给肿瘤局限的患者带来更好的近期疗效，使患者受益，值得在这一部分患者中推广。

Abstract:

Objective To compare the short-term effect of laparoscopic surgery with open surgery for gastrointestinal stromal tumor. Methods 26 patients, whose tumor were localized and the pathologic diagnosis were gastrointestinal stromal tumor in stomach after surgery, were randomly divided into laparoscopic surgery group (n = 12) and open surgery group (n = 14). The age and gender level, disease duration, clinical symptom, tumor location, and the lesion diameter were similar between the two groups (P > 0.05). Surgery achievement, intraoperative blood loss, operative time, postoperative hospital stay, postoperative flatus time, postoperative liquid time, and incidence rates of postoperative complications were compared between the two groups. Results All the patients get successful R0 resection. The volume of intraoperative blood loss, operative time, postoperative hospital stay, postoperative flatus time, and postoperative liquid time in laparoscopic surgery group were lower than open surgery group (P < 0.05). There was no significant difference in the incidence rate of postoperative complications between the two groups (P > 0.05). Conclusion Compared with open surgery, the short-term effect of laparoscopic surgery were better for patients whose gastrointestinal stromal tumor in stomach were localized, and it is worth of promoting clinical application.