结肠癌应用腹腔镜以及开腹手术治疗对机体免疫功能的影响比较

Comparison of the impact of laparoscopic and open surgery on immune function in colon cancer patients

摘要:

目的 研究腹腔镜下结肠癌根治术以及开腹结肠癌根治术对患者免疫功能指标的影响。方法 选取110例于该院接受全结肠系膜切除术（CME）的右半结肠癌患者，根据其不同的手术方式分为观察组以及对照组，观察组采取腹腔镜手术治疗，对照组采取开腹手术治疗，比较两组患者治疗后的炎性应激反应以及治疗前后的相关免疫学指标变化情况。结果 观察组治疗后的炎性应激指标单核细胞趋化因子蛋白-1（MCP-1）、高迁移率族蛋白-1（HMGB-1）、丁二醇（BG）、胰高血糖素均明显优于对照组，治疗后两组白细胞（WBC）、C反应蛋白（CRP）、白细胞介素-6（IL-6）指标较治疗前明显改善，且观察组的CRP、IL-6、CD4+、CD8+和自然杀伤细胞（NK）指标明显优于对照组，组间比较差异有统计学意义（P <0.05）。结论 腹腔镜下CME手术有助于缓解机体的炎性应激反应，且对机体的免疫功能影响较小，值得临床推广应用。

Abstract:

Objective To study the impact of laparoscopic radical resection and open radical resection on immune function in patients with colon cancer. Methods 110 cases received complete mesocolic excision surgery of the right colon cancer patients, according to the different surgical methods divided into observation group and control group, the observation group adopted laparoscopic surgery while the control group treated with open surgery, then compared the inflammatory stress response and related immunology index changes before and after operation. Results After operation, inflammatory stress indicators such as MCP-1, HMGB-1, Glucagon, BG in observation group were significantly better than that in control group. After operation, WBC, CRP, IL-6 index in the two groups were significantly improved. CRP, IL-6, CD4+, CD8+, NK cell index in observation group was significantly better than that in control group. There were significant differences between the two groups, P < 0.05. Conclusion Laparoscopic CME surgery can help to relieve inflammatory stress response, and the immune function is less affected, it is worthy of promoting clinical application.