内镜下聚桂醇注射液硬化治疗食管静脉曲张破裂出血的效果观察*

Endoscopic injection of lauromacrogol sclerotherapy for esophageal variceal hemorrhage caused by rupture*

摘要:

目的 探讨内镜下不同的硬化剂治疗食管静脉曲张破裂出血（EVB）的效果。方法 肝硬化EVB的患者66例，随机分为药物治疗A组、内镜下聚桂醇硬化剂治疗B组和内镜下德国1%乙氧硬化醇硬化剂治疗C组，观察成功止血情况，静脉曲张疗效，以及随访患者出血、发热等不良情况的发生。结果 B组和C组患者止血成功率较A组有明显优势，差异有统计学意义（P <0.05）；B组患者静脉曲张疗效总有效率明显高于A组患者，差异有统计学意义（P <0.05）；B组在早期再出血、迟发性再出血方面较C组少，差异无统计学意义（P > 0.05）；B组发热、溃疡、疼痛情况较C组少，差异有统计学意义（P <0.05）。结论 内镜下聚桂醇注射液硬化治疗EVB是一种安全、迅速、及时、有效且可重复的治疗方法，值得临床上大力推广应用。

Abstract:

Objective To investigate the effect of different endoscopic sclerotherapy for esophageal variceal bleeding caused by rupture. Methods 66 cases of liver cirrhosis with esophageal variceal bleeding were randomly divided into treatment group A, endoscopic lauromacrogol sclerotherapy group B and endoscopic aethoxysklerol 1% German agents in treatment of group C, then observe the successful hemostasis, the curative effect and follow-up of patients with varices, bleeding, fever and other adverse conditions. Results Group B and group C with success rate of hemostasis has obvious advantages compared with group A, P < 0.05, the difference was statistically significant; total effective rate of group B was significantly higher than that in group A, P < 0.05, the difference was statistically significant; early period of rebleeding, delayed again bleeding in group B was occurred less than that of group C, P > 0.05, the difference was not statistically significant; adverse conditions such as fever, ulcers, pain in group B was less than that in group C, P < 0.05, the difference was statistically significant. Conclusion Endoscopic lauromacrogol injection sclerotherapy for esophageal variceal bleeding is a safe, fast speed, timely, effective and repeatable treatment, it is worthy of promoting clinical application.