Abstract:Objective To explore the clinical value of different modes of gastroscope in diagnosis of heterotopic gastric mucosa in upper esophagus (HGMUE). Methods From January 2010 to December 2014, the clinical data of 129 516 cases of outpatient with gastroscopy were analyzed retrospectively. All the patients were divided into four groups: the white light endoscopy group; the white light painless gastroscopy group; Narrow-band imaging(NBI) group; painless NBI group, then compare the differences of detection results. Results 668 cases were found HGMUE, the total detection rate was 0.52%; Detection rate in each group was as followed: white light endoscopy group, 0.21% (144/68 723); white light Painless gastroscopy group, 0.51% (135/26 709); NBI group, 0.93% (263/28 414); painless NBI group, 2.22% (126/5 670). There was statistically difference among the four groups. Conclusion HGMUE could be easily misdiagnosed in gastroscopy, the choice of painless gastroscope NBI mode can improve the detection rate.