Abstract:Objective To investigate multiple endoscopies combination therapy methods and curative effect of complicated upper urinary tract calculi. Methods 435 cases of complex renal and upper ureteral calculi, including 186 cases of ureteral calculi (Stone diameter 0.8~1.5 cm), 112 cases complicated with renal multiple renal calculi (Stone diameter of 0.6~1.2 cm), 96 cases (Stone diameter 0.6~2.2 cm) of simple kidney stones. 42 cases of staghorn stones (Stone diameter 2.0~4.1 cm), we use a period for percutaneous nephrolithotomy treatment, postoperative routine F18 indwelling silicone renal fistula and ureter within double J tube, postoperative routine anti infection treatment of 5~7 d; according to the KUB after operation, 7~10 d after removal of residual stones or renal fistula two period with flexible ureteroscope laser lithotripsy, routine postoperative 2 weeks pulling out ureter within double J tube. Results Ureteroscope into the mirror a success rate of 96.0%, the success of a single stone rate was 74.0% (137/185). The net rate of total row of stones was 100.0% (185/185), operation time of 30~160 min, the average postoperative hospitalization was 7 d, including 4 cases of chills and fever, for percutaneous nephrolithotomy combined with flexible ureteroscope group, the successful rate of puncture was 100.0%, the success of a single stone rate was 100.0% (298/298), the total stone free rate 79.9% (238/298), 36 cases of high fever, chills, 26 cases of delayed hemorrhage. Conclusion A variety of combined endoscope is an effective method for treatment of complex upper urinary tract calculi, it has the advantages of high stone clearance rate, safe, minimally invasive, less complications, is worthy of promoting in clinical practice.