Abstract:Objective To discuss which is more efficient between Needle-knife precut and Plough-knife precut in difficult biliary cannulation. Methods The difference in the average time of cannula, percentage of cannula achievement and the complication rate between the two kinds of operation were compared. Results The percentage of cannula achievement about the Needle-knife precut is higher than Plough-knife precut, while there is no notable difference in average time of cannula and the complication rate between the two precuts. Conclusion Needle-knife precut is more efficient than Plough-knife precut in difficult biliary cannulation, if guide wire can not get into pancreatic duct.