不同温度水灌注肠镜的动物实验研究*

Experimental animal colonoscopy with different temperatures of water infusion*

摘要:

目的  观察不同温度水灌注对兔肠黏膜损伤和肠镜操作的影响。方法  30只体重约1.6～2.5 kg的普通级、成年雄性家兔，随机分成3组：A组（35～36℃）、B组（37～38℃）和C组（39～41℃），行注水结肠镜检查，术中评估操作者满意度，术后光镜观察肠黏膜组织病理学改变。结果  3组肠黏膜损伤情况比较差异无统计学意义（P >0.05），C组肠腔视野暴露评分最低，差异有统计学意义（P <0.05）。结论  温水灌注肠镜是一种安全、有效的方法，其中39～41℃为最佳温度。

Abstract:

Objective To explore the impact on rabbit intestinal mucosa injury and the influence on endoscopic operation with different temperatures of water infusion. Methods 30 common adult male rabbit (weight 1.6～2.5 kg), were randomly divided into three groups with different temperatures of water infusion as follows: A group (35 ～ 36 ℃), B group (37～38 ℃), C group (39～41 ℃), then, perform water infusion colonoscopy, evaluating the operators satisfaction, then we observe the pathological changes of postoperative intestinal mucosal tissue. Results There was no statistically significant difference among the three groups of intestinal mucosa injury (P > 0.05). The vision exposure score of Group C was lowest, compared with the other two groups, which has a statistically significant differences (P < 0.05). Conclusions Warm water infusion colonoscopy is a safe and effective method, and the optimum temperature was about 39～41℃.