Abstract:Abstract: Objectives To investigate the clinical value of transurethral seminal vesiculoscopy in treatment of obstructive and severe oligospermia. Methods 25 patients with EDO (17 cases were azoospermia, 8 cases were severe oligospermia) were selected and treated by transurethral seminal vesiculoscopy, then followed up 6~12 months after operation. Results Sperms were found in semen specimens of 78.6% patients with azoospermia while three month follow-up and accompanied with semen volume increased (0.89 ± 0.14) ml vs (2.80 ± 0.75) ml, pre-operation vs post-operation (P < 0.01); The same tendency was found in patients with oligospermia. Total pregnancy rate was 27.3 % 9 months post-operation. No complications such as retrograde ejaculation, incontinence or rectal injury, et al. were found. Conclusion Transurethral seminal vesiculoscopy is safe and effective for treatment of obstructive azoospermia and severe oligospermia.