Abstract:Abstract: Objective To explore the clinical application of endoscopic nasobiliary drainage in laparoscopic common bile duct exploration and primary suture. Methods Sixty-two cases of common bile duct stone patients were divided into two groups randomly. Study Group underwent nasobiliary drainage associated with laparoscopic common bile duct exploration and primary suture, while control group received laparoscopic common bile duct exploration and T-tube drainage. The clinical data were analyzed between the two groups. Results The operation were successfully completed by laparoscope in both groups. Compared with the controls, the recovery time of intestinal function, the extubation time and the postoperative hospitalization time in the study group was significantly reduced (P < 0.05). There were no significantly difference in the operation time, the intraoperative blood loss, and the incidence of bile leakage between the two groups (P > 0.05). All the patients were fellow up for 6~12 months (average, 9 months), no complications such as biliary stricture and residual stones were found. Conclusion Nasobiliary drainage is feasible, safe and effective. It can drain away bile effectively, reduce biliary pressure, ensure the safety of the primary suture, improve patient's satisfaction and shorten hospital stay.